Channel epithelium malfunction Breath Causes Allergies

Research on the mechanisms of allergy has focused on understanding the imunorespon abnormalities, but several recent new developments realized that the role of the epithelium as the first defense system against allergies started to realize. However, so far not known why and how the allergy is transported through the epithelium. Due to the above, two groups of researchers from the Finnish team reported that one possibility for the development of allergies caused by the malfunction (interference function) respiratory epithelium that allows allergy bound, signed and then browse the epithelium.
Group of researchers from Helsinki University and Helsinki University Central Hospital in collaboration with Findlandia research group, conducted a study to clarify what happened to ygn epithelium, immediately after exposure to allergens and before the onset of allergic reactions.
The research team is using the exposure to pollen allergens (pollen pollen (birch (Bet v1) and show that these allergens are bound, in and browse through the conjunctiva and the nasal epithelium of patients within 1 minute after exposure, but this does not occur in healthy subjects .
In this study more clearly seen that during the spring, in patients allergic, pollen allergens were hundreds of genes changed expression in nasal epithelium, compared to samples taken in winter. Some of these genes associated with transport and regulatory proteins Cytoskeleton. An amazing discovery is that the immune response in healthy control group on exposure to pollen allergens is a strong character and hundreds of genes changed expression during the winter and spring. However, most of these genes associated with immune response functions.
Professor Risto Renkonen who led the study stated that they were not able to explain the mechanism of how the birch pollen allergen bet v1 browse through the epithelium in allergic patients, but not in subjects healthy.
Such transport mechanisms are also used by a variety of bakery and virus attacks when merke epithelium and infect the patient.
In this study used a systematic approach to biological and acquired data simultaneously through a variety of different methods and included in the massive data stored to allow analysis of the role of various proteins and tissues in the pathogenesis of allergic reactions.
Reductionistic analysis, such as those focused only on one or a few molecules gradually replaced by a systematic approach. The ability to find new mechanisms relevant etiologik, is the main motivation for exploration without bias.
Experimental losses are the top-down is that this method requires very expensive, However the yield more than the raw data-based approach to generate hypotheses that can be very much data.